Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum

Author(s)
Yong Hua, Daniel Häussinger, Marcel Mayor, Valentin Köhler, Marcel Strauss, Martin F.X. Mauser, Tim Kostersitz, Philipp Geyer, Markus Arndt
Abstract

Controlling the charge state of biomolecules in high vacuum enables experiments in molecular physics and physical chemistry, particularly in applications of mass spectrometry, trapping and cooling, spectroscopy and matter-wave interferometry. Here we investigate the synthesis, verification and gas phase photolysis of nitrodibenzofuranmethyl aryl ether derivatives. These photocages are chosen because their absorption maximum can be tuned to near 355 nm, where intense pulsed laser light is available. We demonstrate efficient gas-phase cleavage of a photoactive nitrodibenzofuranmethyl aryl ether derivative, both free and attached to oxytocin. This enables the neutralization of a polypeptide derivative in high vacuum using a wavelength outside the absorption spectrum of natural amino acids.

Organisation(s)
Quantum Optics, Quantum Nanophysics and Quantum Information
External organisation(s)
Universität Basel
Journal
Helvetica Chimica Acta
Volume
108
No. of pages
9
ISSN
0018-019X
DOI
https://doi.org/10.1002/hlca.202400167
Publication date
12-2024
Peer reviewed
Yes
Austrian Fields of Science 2012
104017 Physical chemistry, 104026 Spectroscopy
Keywords
ASJC Scopus subject areas
Catalysis, Biochemistry, Drug Discovery, Physical and Theoretical Chemistry, Organic Chemistry, Inorganic Chemistry
Portal url
https://ucrisportal.univie.ac.at/en/publications/f2773d15-a5ac-4c45-a707-955589deb11b