Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum
- Author(s)
- Yong Hua, Daniel Häussinger, Marcel Mayor, Valentin Köhler, Marcel Strauss, Martin F.X. Mauser, Tim Kostersitz, Philipp Geyer, Markus Arndt
- Abstract
Controlling the charge state of biomolecules in high vacuum enables experiments in molecular physics and physical chemistry, particularly in applications of mass spectrometry, trapping and cooling, spectroscopy and matter-wave interferometry. Here we investigate the synthesis, verification and gas phase photolysis of nitrodibenzofuranmethyl aryl ether derivatives. These photocages are chosen because their absorption maximum can be tuned to near 355 nm, where intense pulsed laser light is available. We demonstrate efficient gas-phase cleavage of a photoactive nitrodibenzofuranmethyl aryl ether derivative, both free and attached to oxytocin. This enables the neutralization of a polypeptide derivative in high vacuum using a wavelength outside the absorption spectrum of natural amino acids.
- Organisation(s)
- Quantum Optics, Quantum Nanophysics and Quantum Information
- External organisation(s)
- Universität Basel
- Journal
- Helvetica Chimica Acta
- Volume
- 108
- No. of pages
- 9
- ISSN
- 0018-019X
- DOI
- https://doi.org/10.1002/hlca.202400167
- Publication date
- 12-2024
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104017 Physical chemistry, 104026 Spectroscopy
- Keywords
- ASJC Scopus subject areas
- Catalysis, Biochemistry, Drug Discovery, Physical and Theoretical Chemistry, Organic Chemistry, Inorganic Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/f2773d15-a5ac-4c45-a707-955589deb11b